Drugs can cause fulminant liver failure. The most common and notorious is acetaminophen, the active ingredient of Tylenol and many other over-the-counter pain relievers.
Other drugs and substances that can injure the liver include alcohol, cocaine, ecstasy (a form of methamphetamine), toluene, trichloroethylene and phencyclidine. Herbal medicines and toxic plants like the notorious mushroom amanita phalloides also can cause fulminant liver failure. Workplace exposure to industrial agents may produce liver injury.
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